贺凯（1985-），博士，副教授，湖南省青年骨干教师。研究方向为治疗糖尿病、高血脂等疾病的天然药物研究与开发。

教育及工作经历：

2012/08–至今 湖南医药学院，教师

2017/09–2018/10，美国普渡大学，生物化学，联合培养博士

2014/08–2017/06，西南大学，生物药学，博士

2009/09–2012/06，西南大学，生物化学与分子生物学，硕士

2005/09–2009/06，西南大学，生命科学专业，学士

承担的主要科研项目:

1.湖南省教育厅优秀青年课题(13B088)，主持

2.湖南省科技厅课题（2013FJ6072），主持

3.教育部中央高校基本科研业务费专项课题（XDJK2016D061），主持

4.国家十三五中医药现代化重大专项（2017YFC1702600），参与

5.湖南省自然科学基金青年项目（2019JJ50419），主持

6.湖南省教育厅重点项目（18A488），主持

7.湖南医药学院青年学者培育项目，主持

代表论文：

1.贺凯,杨勇,李树平，李学刚。线粒体功能损伤及靶向线粒体的抗氧化和抗癌药物研发进展。中国新药与临床杂志。2014,33(8):553-558。

2.贺凯,李学刚,陈红英,等。薄层色谱-荧光法测定黄连生物碱分配系数.分析化学。2011, 4: 572 – 576。

3.Kai He, Xue gang Li，Xin Chen, etal. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. Journal of Ethnopharmacology. 137(2011)：1135 - 1142.

4.Kai He,Xuegang Li , Xiaoli Ye, etal. Separation of two constituents from purple sweet potato by combination of silica gel column and high- speed counter-current chromatography. Journal of Chromatography B. 2012(881–882): 49-54.

5.Kai He, Xuegang Li , Xiaoli Ye，etal. A rapid mitochondria-based assay using DCFH oxidation for the determination of antioxidant properties of Chinese herbs. Food Research International. 2012（48）：454-461.

6. Yong Yang , Zaiqi Zhang，Shuping Li, XiaoliYe, Xuegang Li，Kai He（通讯作者）. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia.2014，92：133-147.

7.Kai He, Xiaoli Ye, Hao Wu, Yanzhi Wang Zongyao Zou, Na Ning, Yinran Hu, Biao Chen, Xuedong Fang, Xuegang Li*. The Safety and Anti-Hypercholesterolemic Effect of Coptisine in Syrian Golden Hamsters. Lipids. 2015, 50:185–194.

8.Kai He, Shanghua Song, Zongyao Zou, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli Ye. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytotherapy research. 30(2016):283-291.

9.Kai He, Zongyao Zou, Yinran Hu , Yong Yang, Yubo Xiao, Pincao Gao, Xuegang Li, Xiaoli Ye.Purification ofα-glucosidase from mouse intestine by countercurrent chromatography coupled with a reverse micelle solvent system. Journal of separation science. 2016, 39，703–708.

10.Kai He, Shuming Kou, Zongyao Zou, Yinran Hu, Min Feng, Bing Han, Xuegang Li, Xiaoli Ye. Hypolipidemic Effects of Alkaloids from Rhizoma Coptidis in Diet-Induced Hyperlipidemic Hamsters. Planta Medica. 2016; 82(08): 690-697.

11.Kai He, Yinran Hu, Hang Ma, Zongyao Zou, Yubo Xiao, Yong Yang, Min Feng, Xuegang Li, Xiaoli Ye. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2016 (1862)：1696-1709.

12.Kai He, Xuegang Li,Yubo Xiao,Yang Yong,Zaiqi Zhang,Shuping Li,Taimei Zhou,Daqing Yang,Pincao Gao, Xiaoliang Xin. Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.Food & Function.2016, 7(8):3505-3515.

13.Kai He; Hang Ma; Heshan Xu; Zongyao Zou; Min Feng; Xuegang Li; Xiaoli Ye. Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver. Journal of Functional Foods. 2017，35 (2017):205-215.

14.Kai He, Zhe Li; Longfei Liu; Mengxi Zheng; Chengde Mao*. Assembly of a DNA origami Chinese Knot by Only 15% of the Staple Strands .ChemBioChem, 2020,21.